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Vikram, B. S.
- Synthesis and Screening of Biphenyl Ether Derivatives for their Anti-Inflammatory and Analgesic Activity
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The compounds have been characterized on the basis of preliminary methods, spectral data and tested for anti-inflammatory activity and compared with standard drug as per the standard drug rat hind paw edema method by using Plethesimograph and analgesic activity by Eddies-hotplate method. Among the derivatives prepared, few showed the moderate activity and few showed decreased activity.
Authors
Affiliations
1 Karnataka College of Pharmacy, #33\2, Thirumenahalli, Hegde Nagar Main Road, Yelahanka, Hobli, Jakkur Post, Bangalore-560064, IN
1 Karnataka College of Pharmacy, #33\2, Thirumenahalli, Hegde Nagar Main Road, Yelahanka, Hobli, Jakkur Post, Bangalore-560064, IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 2 (2010), Pagination: 308-311Abstract
Nimesulide (Biphenyl Ether) derivatives were synthesized by four steps, Step-1-Ulmaan ether synthesis, Step-2-Reduction of NO2, Step-3-Condensation reaction, Step-4-Nitration and evaluated for their anti-inflammatory and analgesic activities.The compounds have been characterized on the basis of preliminary methods, spectral data and tested for anti-inflammatory activity and compared with standard drug as per the standard drug rat hind paw edema method by using Plethesimograph and analgesic activity by Eddies-hotplate method. Among the derivatives prepared, few showed the moderate activity and few showed decreased activity.
Keywords
Biphenyl Ether Derivatives, Phenoxy Methane Sulphonamide Derivatives, Non-Steroidal Anti-Inflammatory and Analgesic Drugs.- Synthesis and In Vitro Antifungal and Anthelmintic Activity Studies of Some Substituted Aryloxy-4-Thiazolidinones
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Authors
Affiliations
1 Karnataka College of Pharmacy, #33\2, Thirumenahalli, Hegde Nagar Main Road, Yelahanka Hobli, Jakkur Post, Bangalore-560064, IN
1 Karnataka College of Pharmacy, #33\2, Thirumenahalli, Hegde Nagar Main Road, Yelahanka Hobli, Jakkur Post, Bangalore-560064, IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 2 (2010), Pagination: 508-512Abstract
The results have shown that the Aryloxy-4-thiazolidinone derivatives are found to be effective anti-bacterial agents. The synthesized compounds were elucidated by spectral data. By analysis of IR, NMR and MASS spectral data the compounds reveals the successful information of Aryloxy-4-thiazolidinone derivatives. The synthesized compounds were screened for their anti-bacterial activities by using standard as ampicilin and are found to be effective chemotherapeutic agent. The synthesis of Thiazolidinones by the described methods resulted in the products with good yield.Keywords
Aryl Oxy Ethyl Acetate, Schiff Bases, Aryl Oxy Acethydrazide, Ethyl Chloroacetate, Phenol.- Synthesis and In Vitro Antimicrobial Activity of Some New 3, 5 Di-Substituted Pyrazoline Derivatives
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Authors
Affiliations
1 Karnataka College of Pharmacy, 33/2, Thirumenahalli, Hegde Nagar Main Road, Yelahanka, Hobli, Jakkur Post, Bangalore-560064, IN
1 Karnataka College of Pharmacy, 33/2, Thirumenahalli, Hegde Nagar Main Road, Yelahanka, Hobli, Jakkur Post, Bangalore-560064, IN
Source
Asian Journal of Research in Chemistry, Vol 2, No 3 (2009), Pagination: 285-288Abstract
Pyrazoline derivatives are found to be chemotherapeutically active and they are found to possess anti-inflammatory, anti-bacterial, anti-viral and analgesic activities. The objective of the dissertation work is to synthesize and characterization of 3,5-di-substituted pyrazolines and also to study their anti-bacterial activities.The method followed to synthesize 3,5 di-substituted pyrazolines are as follows: The results have shown that the 3,5 di-substituted pyrazoline derivatives are found to be effective anti-bacterial agents. The synthesized compounds were elucidated by spectral data. By analysis of IR, NMR and MASS spectral data the compounds reveals the successful information of 3,5-di-substituted pyrazolines and also about different aromatic groups at position 3 and 5.The synthesized compounds were screened for their anti-bacterial activities by using standard as ampicillin and are found to be effective chemotherapeutic agent. The synthesis of pyrazolines by the described methods resulted in the products with good yield.Keywords
Chalcones, Pyrazolines, Heterocyclic Compound, Anti-Bacterial.- Synthesis and In Vitro Antibacterial Activity Studies of Some Substituted Aryloxy-4-Thiazolidinones
Abstract Views :146 |
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Authors
Affiliations
1 Karnataka College of Pharmacy, #33\2, Thirumenahalli, Hegde Nagar Main Road, Yelahanka, Hobli, Jakkur Post, Bangalore-560064, IN
1 Karnataka College of Pharmacy, #33\2, Thirumenahalli, Hegde Nagar Main Road, Yelahanka, Hobli, Jakkur Post, Bangalore-560064, IN